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WOYF 23: Collagen noninvasive crosslinking mechanism, characterization and applications

Time:Jul 3, 2019

Speaker:Dr. Wang Chao , Columbia University

Invited by:Dr. Cao Xiangdong

Time:09:30-11:00, July 5, 2019
Venue: A101


Abstract:

The prevalence of myopia has increased worldwide over the last 50 years. Its incidence in the United States and Europe is now almost twice that 50 years ago, and it is even more prevalent in East Asia. Spectacles and contact lenses remain the most common means of vision correction, but the permanent correction of refractive errors, by refractive surgery, has emerged as an attractive alternative. However, such surgery is an invasive procedure that may compromise corneal structure, and post-surgical complications have been reported. We propose a novel, non-invasive approach to permanent vision correction based on a different mode of laser–cornea interaction. Our approach induces the formation of a low-density plasma that produces reactive oxygen species, which react with the surrounding proteins, forming crosslinks and triggering spatially resolved changes in mechanical properties. We show that the proposed method changes the refractive power of the eye, and confirm its safety and stability. Furthermore, together with the research of Raman characterization of early stage osteoarthritis, the proposed novel technique was also applied to provide new treatment options.


Biography:

Chaois currently a PhD candidate in Columbia University and Columbia University Medical Center's Eye Institute. His research interest is novel noninvasive collagen crosslinking mechanism, characterization and applications. One of the most important applications is noninvasive vision correction, and this work has been published as cover article on Nature Photonics.

Prev:WOYF 24: Laser additive nano-manufacturing & ultrasensitive sensing

Next:WOYF 22: Precision glass molding technology for micro/nano structures

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  • Ministry of Science and Technology of the People’s Republic of China
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